Human Longevity Inc.’s Open Search provides researchers access to the data on over 10,000 genomes.* This browser-based search supports efforts to understand human genetic diversity and empowers researchers to quickly search through our genomic database. This database contains more than 200 million variants that are linked to ClinVar and other trusted databases.

  • Simple query-based search
  • Fast, robust, and powerful whole genome analysis
  • Access to allele frequencies of 10,000 whole genomes
  • Seamless links to many genome resources

Deep Sequencing of 10,000 Genomes

We report on the sequencing of 10,545 human genomes at 30x to 40x coverage with an emphasis on quality metrics and novel variant and sequence discovery. We find that 84% of an individual human genome can be sequenced confidently. This high-confidence region includes 91.5% of exon sequence and 95.2% of known pathogenic variant positions. We present the distribution of over 150 million single-nucleotide variants in the coding and noncoding genome. Each newly sequenced genome contributes an average of 8,579 novel variants. In addition, each genome carries on average 0.7 Mb of sequence that is not found in the main build of the hg38 reference genome. The density of this catalog of variation allowed us to construct high-resolution profiles that define genomic sites that are highly intolerant of genetic variation. These results indicate that the data generated by deep genome sequencing are of the quality necessary for clinical use.

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*www.pnas.org/cgi/doi/10.1073/pnas.1613365113

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HLI Open Search Privacy Policy

We at Human Longevity, Inc. (“HLI”) know that our users care about how your personal information is used and shared, and we take your privacy seriously.  Please read the following to learn more about our Privacy Policy.  By visiting or using HLI Open Search in any manner, you acknowledge that you accept the practices and policies outlined in this Privacy Policy, and you hereby consent that we will collect, use, and share your information in the following ways. Any capitalized terms used herein without definition shall have the meaning given to them in the HLI Open Search Terms of Use.

I. What does this Privacy Policy cover?

This Privacy Policy covers our treatment of personally identifiable information (“Personal Information”) that we gather when you are accessing or using HLI Open Search.  This policy does not apply to the practices of companies that we do not own or control, or to individuals that we do not employ or manage.

We do not knowingly collect or solicit personal information from anyone under the age of 13 or knowingly allow such persons to register for HLI Open Search. If you are under 13, please do not attempt to register for HLI Open Search or send any information about yourself to us, including your name, address, telephone number, or email address. No one under age 13 may provide any personal information to us or on HLI Open Search. In the event that we learn that we have collected personal information from a child under age 13 without verification of parental consent, we will delete that information as quickly as possible. If you believe that we might have any information from or about a child under 13, please contact us at privacyofficer@humanlongevity.com.

II. What information does HLI collect?

We gather Personal Information from our users, as explained more fully below.  We may use this Personal Information to personalize and improve our products and services, to contact users, to fulfill your requests for certain services, to analyze how users utilize HLI Open Search, and as otherwise set forth in this Privacy Policy. We may share certain types of Personal Information with third parties (described in this Section and in Section III below).  We collect the following types of information:

A. Information You Provide to Us: We receive and store any information you knowingly provide to us.

B. Information Collected Automatically: Whenever you interact with HLI Open Search, we automatically receive and record information on our server logs from your browser including your IP address, “cookie” information, and the page you requested. “Cookies” are identifiers we transfer to your computer or mobile device that allow us to recognize your browser or mobile device and tell us how and when pages in HLI Open Search are visited and by how many people.  You may be able to change the preferences on your browser or mobile device to prevent or limit your computer or device’s acceptance of cookies, but this may prevent you from taking advantage of some features of HLI Open Search.  If you click on a link to a third party website, such third party may also transmit cookies to you.  This Privacy Policy does not cover the use of cookies by any third parties.

Certain usage information we collect (such as the numbers and frequency of visitors to HLI Open Search), we only use in aggregate form, and not in a manner that would identify you personally.  For example, this aggregate data tells us how often users use parts of HLI Open Search, so that we can make HLI Open Search appealing to as many users as possible.  We may also provide this aggregate information to our partners; our partners may use such information to understand how often and in what ways people use HLI Open Search, so that they, too, can provide you with an optimal experience. However, our data capture and analysis tools, and other similar tools may also capture your identifiable data. For example, it may be possible for us to associate your queries with your identity. We will not use such identifiable data for any purposes other than to operate, promote, and improve HLI Open Search, other HLI products and services and to develop new ones.

III. Will HLI share any of the Personal Information it receives?

We neither rent nor sell your Personal Information in personally identifiable form to anyone. We share your Personal Information in personally identifiable form with third parties as described below.

A. Agents: We employ other companies and people to perform tasks on our behalf and need to share your information with them to provide products or services to you.    Unless we tell you differently, our agents do not have any right to use the Personal Information we share with them beyond what is necessary to assist us.

B. Business Transfers: We may choose to buy or sell assets.  In these types of transactions, customer information is typically one of the business assets that would be transferred.  Also, if we (or substantially all of our assets) are acquired, or if we go out of business, enter bankruptcy, or go through some other change of control, Personal Information would be one of the assets transferred to or acquired by a third party.

C. Protection of HLI and Others:We reserve the right to access, read, preserve, and disclose any information that we reasonably believe is necessary to comply with law or court order; enforce or apply our conditions of use and other agreements; or protect the rights, property, or safety of HLI, our employees, our users, or others.  This includes exchanging information with other companies and organizations for fraud protection and credit risk reduction.

D. With Your Consent:Except as set forth above, you will be notified when your Personal Information may be shared with third parties in personally identifiable form, and will be able to prevent the sharing of this information.

IV. Is Personal Information about me secure?

We endeavor to protect the privacy of your Personal Information we hold in our records, but we cannot guarantee complete security. Unauthorized entry or use, hardware or software failure, and other factors, may compromise the security of user information at any time.

HLI Open Search may contain links to other sites. We are not responsible for the privacy policies and/or practices on other sites. When following a link to another site you should read that site’s privacy policy.

V. What Personal Information can I access?

If you have any questions about viewing or updating information we have on file about you, please contact us at privacyofficer@humanlongevity.com. Under California Civil Code Sections 1798.83-1798.84, California residents are entitled to ask us for a notice identifying the categories of Personal Information which we share with our affiliates and/or third parties for marketing purposes, and providing contact information for such affiliates and/or third parties.  If you are a California resident and would like a copy of this notice, please submit a written request to: privacyofficer@humanlongevity.com.

VI. What choices do I have?

You can always opt not to disclose information to us, but keep in mind some information may be needed to register with us or to take advantage of some of our special features.

You may be able to add or update information as explained in Section V above.  When you update information, however, we may maintain a copy of the unrevised information in our records.

VII. Changes to this Privacy Policy

We may amend this Privacy Policy from time to time.  Use of information we collect now is subject to the Privacy Policy in effect at the time such information is used.  If we make changes in the way we use Personal Information, we will notify you by posting an announcement on HLI Open Search or sending you an email.  You are bound by any changes to the Privacy Policy when you use HLI Open Search after such changes have been first posted.

VIII. Questions or Concerns

If you have any questions or concerns regarding our privacy policies, please send us a detailed message to privacyofficer@humanlongevity.com, and we will try to resolve your concerns.

Effective Date: October 24, 2016

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HLI OPEN SEARCH TERMS OF USE

Thanks for using HLI Open Search. HLI Open Search is provided by Human Longevity, Inc. (“HLI”), located at 4570 Executive Drive, San Diego, CA 92121, United States. By using HLI Open Search, you are agreeing to these terms. Please read them carefully.

Using HLI Open Search

You must follow any policies made available to you within HLI Open Search.

Don’t misuse HLI Open Search. For example, don’t interfere with HLI Open Search or try to access HLI Open Search using a method other than the interface and the instructions that we provide. You may use HLI Open Search only as permitted by law, including applicable export and re-export control laws and regulations. We may suspend or stop providing HLI Open Search to you at any time for any reason, including if you do not comply with our terms or policies or if we are investigating suspected misconduct.

By using HLI Open Search, you acknowledge and agree that HLI Open Search, and any content and/or results of HLI Open Search, are not intended to be medical advice or instructions for medical diagnosis, treatment or care of persons, and no physician-patient relationship is, or is intended to be, created by HLI Open Search, and any content and/or results of HLI Open Search. HLI Open Search and any content and/or results of HLI Open Search, are not a substitute for professional medical advice, examination, diagnosis or treatment and should not be used to diagnose, treat, cure, or prevent disease.

Using HLI Open Search does not give you ownership of any intellectual property rights in HLI Open Search or the content you access. You may not use content from HLI Open Search unless you obtain permission from its owner or are otherwise permitted by law. These terms do not grant you the right to use any branding or logos used in HLI Open Search. Don’t remove, obscure, or alter any legal notices displayed in or along with HLI Open Search.

Except for the limited right to use HLI Open Search or as otherwise expressly set forth in these terms, we do not grant you additional license(s) of any kind, whether by implication, estoppel or otherwise. You have not provided and will not provide, and we have not received and will not receive, any consideration except that which is expressly provided herein for the specific rights expressly granted to you under these terms. All rights in and to HLI Open Search that we do not expressly grant to you in these terms are expressly reserved for us and/or our licensors or suppliers, as applicable.

HLI Open Search displays some content that is not HLI’s. This content is the sole responsibility of the entity that makes it available. We may review content to determine whether it is illegal or violates our policies, and we may remove or refuse to display content that we reasonably believe violates our policies or the law. But that does not necessarily mean that we review content, so please don’t assume that we do.

In connection with your use of HLI Open Search, we may send you service announcements, administrative messages, and other information. You may opt out of some of those communications.

Your HLI Account

You may need an HLI Account in order to use HLI Open Search. You may create your own HLI Account, or your HLI Account may be assigned to you by an administrator, such as your employer or educational institution. If you are using a HLI Account assigned to you by an administrator, different or additional terms may apply and your administrator may be able to access or disable your account.

To protect your HLI Account, keep your password confidential. You are responsible for the activity that happens on or through your HLI Account. Try not to reuse your HLI Account password on third-party applications. You agree to inform us promptly if you learn of any unauthorized use of your password or HLI Account.

Privacy

HLI’s policies explain how we treat your personal data and protect your privacy when you use HLI Open Search. By using HLI Open Search, you agree that HLI can use such data in accordance with applicable law and our policies, including our Privacy Policy.

Your Content in HLI Open Search

Some of HLI Open Search allows you to upload, submit, store, send or receive content. You retain ownership of any intellectual property rights that you hold in that content. In short, what belongs to you stays yours.

When you upload, submit, store, send or receive content to or through HLI Open Search, you give HLI (and those we work with) a worldwide license to use, host, store, reproduce, modify, create derivative works (such as those resulting from translations, adaptations or other changes we make so that your content works better with HLI Open Search), communicate, publish, publicly perform, publicly display and distribute such content. The rights you grant in this license are for the limited purpose of operating, promoting, and improving HLI Open Search, other HLI products and services and to develop new ones. This license continues even if you stop using HLI Open Search. Make sure you have the necessary rights to grant us this license for any content that you submit to HLI Open Search.

HLI’s data capture and analysis tools, and other similar tools may also capture your identifiable data. For example, it may be possible for us to associate your queries with your identity. We will not use such identifiable data for any purposes other than to operate, promote, and improve HLI Open Search, other HLI products and services and to develop new ones. For example, we may analyze your content to provide you personally relevant product features, such as customized search results, tailored advertising, and spam and malware detection. This analysis occurs as the content is sent, received, and when it is stored.

Some content or applications that are accessible through use of HLI Open Search are served by third parties, including content providers and application providers. You acknowledge that, through no involvement of or action by HLI, use of an internet browser subjects your online activity to monitoring by such third parties. These third parties may use cookies, alone or in conjunction with web beacons or other tracking technologies, to collect information about users, including you, when using HLI Open Search to link to the third party content. The information that they collect may be associated with your personal information or they may collect information, including personal information, about your online activities over time and across different websites and other online services. They may use this information to provide you with interest-based (behavioral) advertising or other targeted content. HLI does not control these third parties’ tracking technologies or how they may be used. If you have any questions about an advertisement or other targeted content, you should contact the responsible provider directly.

If you submit feedback or suggestions about HLI Open Search, we may use your feedback or suggestions for any purpose without obligation to you, and you hereby grant to HLI and its successors unrestricted rights to use and fully exploit for any purpose all such feedback and suggestions and to use, reproduce, prepare derivative works of, perform, display, make, sell and otherwise distribute products and services incorporating or utilizing your feedback and suggestions.

Modifying and Terminating HLI Open Search

We are constantly changing and improving HLI Open Search. We may add or remove functionalities or features, and we may suspend or stop HLI Open Search altogether.

You can stop using HLI Open Search at any time. HLI may also stop providing HLI Open Search to you, or add or create new limits to HLI Open Search at any time.

Our Warranties and Disclaimers

We take pride in HLI Open Search and hope you find it useful. But there are certain things that we don’t promise about HLI Open Search.

OTHER THAN AS EXPRESSLY SET OUT IN THESE TERMS OR ADDITIONAL TERMS, NEITHER HLI NOR ITS SUPPLIERS OR DISTRIBUTORS MAKE ANY SPECIFIC PROMISES ABOUT HLI Open Search. FOR EXAMPLE, WE DON’T MAKE ANY COMMITMENTS ABOUT THE CONTENT WITHIN HLI Open Search, THE SPECIFIC FUNCTIONS OF HLI Open Search, OR THEIR RELIABILITY, AVAILABILITY, OR ABILITY TO MEET YOUR NEEDS. WE PROVIDE HLI Open Search “AS IS” AND WITH ALL FAULTS.

SOME JURISDICTIONS PROVIDE FOR CERTAIN WARRANTIES, LIKE THE IMPLIED WARRANTY OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NON-INFRINGEMENT. TO THE EXTENT PERMITTED BY LAW, WE EXPRESSLY EXCLUDE ALL WARRANTIES.

Liability for HLI Open Search

WHEN PERMITTED BY LAW, HLI, AND HLI’S SUPPLIERS AND DISTRIBUTORS, WILL NOT BE RESPONSIBLE FOR LOST PROFITS, REVENUES, OR DATA, FINANCIAL LOSSES OR INDIRECT, SPECIAL, CONSEQUENTIAL, EXEMPLARY, OR PUNITIVE DAMAGES.

TO THE EXTENT PERMITTED BY LAW, THE TOTAL LIABILITY OF HLI, AND ITS SUPPLIERS AND DISTRIBUTORS, FOR ANY CLAIMS UNDER THESE TERMS, INCLUDING FOR ANY IMPLIED WARRANTIES, IS LIMITED TO THE AMOUNT YOU PAID US TO USE HLI Open Search (OR, IF WE CHOOSE, TO SUPPLYING YOU HLI Open Search AGAIN). IN ALL CASES, HLI, AND ITS SUPPLIERS AND DISTRIBUTORS, WILL NOT BE LIABLE FOR ANY LOSS OR DAMAGE THAT IS NOT REASONABLY FORESEEABLE.

Business uses of HLI Open Search

If you are using HLI Open Search on behalf of a business, organization or institution, that business, organization or institution accepts these terms. It will hold harmless and indemnify HLI and its affiliates, officers, agents, and employees from any claim, suit or action arising from or related to the use of HLI Open Search or violation of these terms, including any liability or expense arising from claims, losses, damages, suits, judgments, litigation costs and attorneys’ fees.

About these Terms

We may modify these terms or any additional terms that apply to HLI Open Search to, for example, reflect changes to the law or changes to HLI Open Search. You should look at the terms regularly. Changes will be effective immediately. If you do not agree to the modified terms for HLI Open Search, you should discontinue your use of that Service.

If there is a conflict between these terms and any additional terms provided by HLI, the additional terms will control for that conflict.

These terms control the relationship between HLI and you. They do not create any third party beneficiary rights.

If you do not comply with these terms, and we don’t take action right away, this doesn’t mean that we are giving up any rights that we may have (such as taking action in the future).

If it turns out that a particular term is not enforceable, this will not affect any other terms.

The laws of California, U.S.A., excluding California’s conflict of laws rules, will apply to any disputes arising out of or relating to these terms or HLI Open Search. All claims arising out of or relating to these terms or HLI Open Search will be litigated exclusively in the federal or state courts of San Diego, California, USA, and you and HLI consent to personal jurisdiction in those courts.

For information about how to contact HLI, please visit our contact page.

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